Lab news
2024
Previous news
01/29/2024: Dr. Yu Li was invited to the School of Biological Engineering at Tianjin University of Science and Technology to conduct academic exchanges and deliver an academic report entitled “Nutrient sensing and Metabolic Regulation in the liver - From Basic Research to Application”. Dr. Zhang Cuiying, Vice Dean of the School of Biological Engineering and Vice Dean of the Industrial Innovation Technology Research Institute of the China Alcoholic Drinks Association, hosted this academic report, and teachers and students from relevant majors attended.
04/19/2024: Congratulation to Xiaoyi Wei for the publication of the review entitled “Gestational Diabetes Mellitus: What Can Medical Nutrition Therapy Do?”. This contribution reviews the research progress of medical nutrition treatment in GDM, summarizes the international recommendations on the intake of various nutrients and the influence of nutrients on the prevalence of GDM, and the improvement effect of nutritional intervention on it, in order to provide references for research in related fields of GDM and the targeted development of enteral nutrition.
04/08/2024: Congratulation to Aoyuan Cui, Weitong Su and Yaqian Xue for the publication of the article entitled "Glucose regulation of adipose tissue browning by CBP/p300- and HDAC3-mediated reversible acetylation of CREBZF" in Proc Natl Acad Sci U S A (2024 Apr 16;121(16):e2318935121). When stimulated by low temperature and environmental signals, adipocytes will take up a large amount of glucose, which on the one hand can be used as an energy-supplying substance to directly provide energy for adipocytes, and on the other hand, glucose signaling increases the acetylation modification and protein stability of CREBZF through CBP/p300. This study suggests that CREBZF is a key factor in the sensing glucose signaling pathway, and the dysregulation of glucose sensing by CREBZF plays an important role in the development of obesity and related metabolic diseases caused by energy overconsumption.
04/27/2024: Congratulation to Dr. Weitong Su for receiving DI AO Scholarship (地奥奖学金) Second Prize, CAS.
05/08/2024: Congratulation to PhD degree graduation for Drs. Weitong Su, Genxiang Cai and Yang Jiang. Congratulation to master degree graduation for Yanling Huo. Thank all the thesis defense committee members. Wishing them a bright future!
05/23/2024: Congratulation to Jiaxin Shen, Jing Lin and Mengyao Huang for receiving Merit Student Award (三好学生), SINH, CAS.
05/26/2024: Congratulation to Dr. Weitong Su for receiving Outstanding Graduates of Shanghai Ordinary Colleges and Universities (上海市普通高等学校优秀毕业生).
06/01/2024: Dr. Yu Li was invited to give a presentation entitled “Glucose Sensing by the Adipocyte in Regulating Energy Metabolism” at the Annual Meeting of the Division of Lipids and Lipoproteins of the Chinese Society of Biochemistry and Molecular Biology, Xi’an.
06/18/2024: Dr. Yu Li was invited to give an oral presentation entitled “CREBZF in the Control of Metabolic Diseases” at 2024 the 15th CADA Annual Meeting. Dr. Weitong Su presented a post entitled “Treg cell-mediated immune regulation of adipose inflammation via palmitic acid-induced CREBZF”, which was honored with “The inaugural CADA Annual Meeting Travel Award” and “Poster Award”.
06/21/2024: Dr. Yu Li was invited to give an oral presentation entitled “Glucose regulation of adipose tissue browning by CBP/p300 and HDAC3-mediated reversible acetylation of CREBZF” at the 84st Scientific Sessions of American Diabetes Association. Dr. Weitong Su was invited to give an oral presentation entitled “Palmitic acid coordinates impaired adipose tissue ICOS high Treg immunosuppression and systemic metabolic disturbance during obesity”.
08/09/2024: Dr. Yu Li was invited to give a talk entitled “Macrophage CREBZF exacerbates chronic inflammatory and insulin resistance via the crosstalk between ATM and adipocytes” at the 21st Annual Meeting of Chinese Society of Endocrinology (CSE), Suzhou.
09/10/2024: Happy teacher’s day!
09/15/2024: Jing Gao and Lianjia Li participated in the singing contest of SINH to welcome the 75th anniversary of the National Day and won the third prize.
01/29/2024: Congratulation to Yuxiao Liu, Weitong Su and Zhengshuai Liu for the publication of the article entitled “Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes” in Advanced Science (2024 Apr;11(13):e2306685). In obesity development, hyperactivation of macrophage CREBZF increases NF-κB signaling pathway activity by competitively binding p65 with IκBα, thereby accelerating adipose tissue chronic inflammatory response and insulin resistance. This study identifies a previously unknown role of CREBZF coupling ATM activation to systemic insulin resistance and type 2 diabetes.
10/29/2024: Dr. Yu Li was invited to give a talk entitled “Metabolic control of type 2 diabetes and MASLD” at the School of Basic Medical Sciences at Peking University, Beijing.
11/08/2024: Congratulations to Dr. Aoyuan Cui for being awarded “Venus A” of Shanghai Science and Technology Innovation Action Plan 2024 (上海市2024年度“科技创新行动计划”启明星A类) . Congratulations to Dr. Weitong Su for receiving the support of Shanghai Science and Technology Innovation Action Plan 2024 Top Level Program (上海市2024年度“科技创新行动计划”面上项目).
11/10/2024: Congratulation to Dong Ding and Jing Lin for receiving National Scholarship (国家奖学金).
11/14/2024: Dr. Yu Li was invited to attend and give a talk entitled “Liver metabolism regulation and body health” at the Chinese Diabetes Association (CDS)’s 26th scientific meeting in Nanjing.
11/16/2024: Haokai Yu completed the Changzhou Xinbei Half Marathon (常州新北半程马拉松) with excellent results.
11/17/2024: Dr. Yu Li was invited to attend and give a talk entitled “Insights into the mechanism for therapeutic effects of FGF21 on liver fibrosis” at 2024 World Youth Scientists Summit (WYSS) Health Forum, and 6th International Symposium on Innovation and Transformation of Fibroblast Growth Factors (FGF), Wenzhou, Zhejiang.
11/19/2024: Dr. Yu Li was invited as a keynote speaker to give a talk entitled “Liver metabolism regulation and body health” at the Annual Conference of the Brewing Branch of the Chinese Society of Microbiology, and the Innovation Development Forum of the Chinese Liquor Industry, Zunyi (贵州遵义), Guizhou.
11/25/2024: Mengyao Huang participated in the “Keyuan Cup” (科苑杯) badminton tournament organized by the UCAS.
11/29/2024: Dr. Xiaohe Luo and Dong Ding participated in and won the first CNS Cup futsal tournament (第一届CNS杯五人制足球赛). Congratulations to Dr. Xiaohe Luo for honored with the Golden Boot of the tournament and Dong Ding for the MVP of the tournament!
12/11/2024: Congratulation to Dr. Yang Jiang and Shuang Wei for the publication of the article entitled “Ethyl Lactate Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcohol-Associated Liver Disease by Inducing Fibroblast Growth Factor 21” in Advanced Science (2024 Dec 11:e2409516.). Aberrant upregulation of hepatic lipogenesis induced by chronic and excessive alcohol consumption is a critical driver of the progression of alcohol-associated liver disease (ALD). It is shown that the activator ethyl lactate, a nonethanol ingredient found in distilled liquors, ameliorates alcoholic hepatosteatosis, inflammation and acute-on-chronic liver injury by stimulating FGF21. The regulatory mechanism is discussed during the pathophysiological conditions and suggests new lines of research into the therapeutic use of a foodborne small molecule ethyl lactate.
12/13/2024: Dr. Aoyuan Cui was invited to give an oral presentation entitled “Post-translational modification of proteins and homeostatic regulation of glycolipid metabolism” at the 2024 Pujiang Annual Conference on Obesity and Metabolism (2024年浦江肥胖与代谢学术年会). Her presentation was selected as “the best youth paper presentation award” (最佳青年论文报告奖).
12/20/2024: The Lilab team embarked on an exhilarating five-day, four-night team-building retreat to the tropical paradise of Phuket, Thailand(泰国普吉岛). This adventure was not just a break from the daily grind but an opportunity for team members to bond, learn, and grow together in an environment that fostered creativity and unity.
Day 1: Arrival and Orientation
Upon arrival, the team was greeted by the warm, tropical air and the lush greenery that Phuket is famous for. After checking into Patong Cultural Heritage Hotel(芭东文化遗址酒店), the team was briefed on the exciting itinerary that lay ahead. The anticipation was palpable as everyone looked forward to the adventures that awaited them.
Day 2: Island Hopping and Snorkeling(跳岛和浮潜)
The second day was dedicated to island hopping and snorkeling, activities that allowed the team to explore the breathtaking underwater world of Phuket. Armed with snorkels and diving masks(呼吸管和面镜), the Lilab members dove into the crystal-clear waters, marveling at the vibrant coral reefs and the diverse marine life. The experience was not only thrilling but also educational, as team members learned about the importance of marine conservation and the delicate balance of the ecosystem.
As they hopped from island to island, the team shared laughter and stories, their bonds strengthening with each shared experience. The joy of discovery was evident on their faces as they floated above the water, taking in the wonders beneath them.
Day 3: Seafood Feast(海鲜大餐) and Cultural Exploration
On the third day, the team indulged in a seafood feast that was a true testament to Phuket's culinary prowess in. Freshly caught fish, succulent prawns, and a variety of other seafood delicacies were served, delighting the taste buds of the Lilab team. The meal was not just about satisfying their appetites but also about experiencing the rich cultural heritage of Thai cuisine.
Following the feast, the team embarked on a cultural exploration of the island in Phuket town(普吉镇), visiting local markets, temples(查龙寺), and historical sites. This immersive experience allowed them to gain a deeper understanding of the local way of life and the traditions that have shaped Phuket's identity.
Day 4: Surfing and Kayaking（冲浪和皮划艇）
The fourth day brought a surge of adrenaline with surfing and kayaking adventures. The Lilab team faced the waves with determination and excitement, learning to ride the swells and navigate the waters(乘风破浪). Surfing not only tested their physical abilities but also their mental fortitude, as they learned to balance and synchronize their movements with the rhythm of the ocean.
In the afternoon, the team switched to kayaking, a more serene activity that allowed them to explore the coastline at a slower pace. Paddling in sync, they enjoyed the tranquility of the water and the beauty of the island's natural landscape.
As the sun began to set, the team retreated to the tranquility of a Thai massage parlor(泰式按摩). The day's physical exertion made the massage even more rewarding, as the team members relaxed their muscles and minds, reflecting on the day's achievements and the growing camaraderie among them.
Day 5: Live Fire Shooting Experience(实弹射击)
The final day of the retreat was reserved for a unique and thrilling experience: live fire shooting. The team members were introduced to the basics of firearm safety and handling before moving on to the shooting range. Under the supervision of professional instructors, they fired a variety of weapons, experiencing the adrenaline rush of hitting targets with precision.
This activity was not only about the excitement of shooting but also about trust and responsibility. Team members had to rely on each other for safety and encouragement, further strengthening the bonds formed throughout the retreat.
The Phuket retreat was more than just a vacation; it was a transformative experience for the Lilab team. Through island hopping, snorkeling, indulging in seafood feasts, conquering the waves with surfing and kayaking, and experiencing the thrill of live fire shooting, the team members not only enjoyed themselves but also forged stronger relationships that will undoubtedly contribute to the success of their future projects. As they return to their respective roles, they do so with a renewed sense of purpose and a deeper understanding of the value of teamwork and collaboration.
