2024

1. Cui A#, Xue Y#, Su W#, Lin J, Liu Y, Cai G, Wan Q, Jiang Y, Ding D, Zheng Z, Wei S, Li W, Shen J, Wen J, Huang M, Zhao J, Zhang X, Zhao Y, Li H, Ying H, Zhang H, Bi Y, Chen Y, Xu A, Xu Y*, Li Y*. Glucose regulation of adipose tissue browning by CBP/p300 and HDAC3-mediated reversible acetylation of CREBZF. Proceedings of the National Academy of Sciences. 2024, 121(16):e2318935121

 

2. Liu Y#, Su W#, Liu Z#, Hu Z, Shen J, Zheng Z, Ding D, Huang W, Li W, Cai G, Wei S, Li N, Fang X, Li H, Qin J, Zhang H, Xiao Y, Bi Y, Cui A*, Zhang C*, Li Y*. Macrophage CREBZF orchestrates inflammatory response to potentiate insulin resistance and type 2 diabetes. Advanced Science. 2024, e2306685

 

3. 李于*, 温剑. 非酒精性脂肪性肝炎促进原发性肝癌的病因与防治策略. 西南医科大学学报. 2024, 47(1):1-5.

2023

4. Xue Y#, Cui A#, Wei S, Ma F, Liu Z, Fang X, Huo S, Sun X, Li W, Hu Z, Liu Y, Cai G, Su W, Zhao J, Yan X, Gao C, Wen J, Zhang H, Li H, Liu Y, Lin X, Xu Y, Fu W*, Fang J*, Li Y*. Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism. Proceedings of the National Academy of Sciences. 2023, 120(23):e2219419120Highlighted: Wang C and Zhou Q: Faculty Opinions Recommendation of [Xue Y et al., Proc Natl Acad Sci USA 2023 120(23:e2219419120)]. In Faculty Opinions, 21 Jun 2023;

 

5. Ma F, Liu Y, Hu Z, Xue Y, Liu Z, Cai G, Su W, Zheng Z, Fang X, Yan X, Ding D, Sun X, Jiang Y, Wei S, Li W, Zhao J, Zhang H, Li H, Xiao D, Zhang C, Ying H, Qin J, Gao X, Dai X, Fu W, Xu Y*, Li Y*, Cui A*. Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression. Hepatology. 2023, 78(5):1492-1505

 

6. Lin P, Yan X, Jing S, Wu Y, Shan Y, Guo W, Gu J, Li Y, Zhang H, Li H*. Single-cell and spatially resolved transcriptomics for liver biology. Hepatology. 2023 (online)

 

7. Li G, Chen H, Shen F, Smithson SB, Shealy GL, Ping Q, Liang Z, Han J, Adams AC, Li Y, Feng D, Gao B, Morita M, Han X, Huang TH, Musi N, Zang M*. Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis. Hepatology. 2023, 78(5):1506-1524

 

8. Khambu B, Cai G, Liu G, Bailey N, Mercer A, Baral K, Ma M, Chen X, Li Y, Yin X*. NRF2 Transcriptionally Regulates Caspase-11 Expression to Activate HMGB1 Release by Hepatocytes. Cell Death Discovery. 2023, 9(1):270

 

9. Ma Y, Shen S, Yan Y, Zhang S, Liu S, Tang Z, Yu J, Ma M, Niu Z, Li Z, Wu Y, Zhao L, Lu Z, Wei C, Zhang WJ, Xue Y, Zhai Q, Li Y, Hu C, Jiang J*, Li YY*, Ying H*. Adipocyte thyroid hormone β receptor-mediated hormone action fine-tunes the intracellular glucose and lipid metabolism and systemic homeostasis. Diabetes. 2023, 72(5):562-574

2022

10. Zhao J#, Zou H#, Huo Y, Wei X, Li Y*. Emerging Roles of Selenium on Metabolism and Type 2 Diabetes. Frontiers in Nutrition. 2022, 9:1027629

 

11. Tian C, Min X, Zhao Y, Wang Y, Wu X, Liu S, Dou W, Zhou T, Liu Y, Luo R, Li Z, Lui K, Li Y, Zhou B, Ding Q*. MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM. Journal of Hepatology. 2022, 77(6):1491-1503

 

12. Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B*, Wang H*. Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic Sirtuin 1-C/EBPα-miRNA-223 axis. Hepatology. 2022, 75(3):646-660

 

13. Dai X#, Wang K#, Fan J#, Liu H#, Fan X, Lin Q, Chen Y, Chen H, Li Y, Liu H, Chen O, Chen J, Li X, Ren D, Li J, Conklin DJ, Wintergerst KA, Li Y, Cai L, Deng Z, Yan X*, Tan Y*. Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs. Redox Biology. 2022, 56:102449

 

14. Zou H, Zhang M, Zhu X, Zhu L, Chen S, Luo M, Xie Q, Chen Y, Zhang K, Bu Q, Wei Y, Ye T, Li Q, Yan X, Zhou Z, Yang C, Li Y, Zhou H*, Zhang C*, You X*, Zheng G*, Zhao G*. Ginsenoside Rb1 improves metabolic disorder in high-fat diet-induced obese mice associated with modulation of gut microbiota. Frontiers in Microbiology. 2022, 13:826487

2021

15. Cui A, Ding D, Li Y*. Regulation of hepatic metabolism and cell growth by the ATF/CREB family of transcription factors. Diabetes. 2021, 70(3):653-664

 

16. Zhao Z#, Wang Z#, Zhou D, Han Y, Ma F, Hu Z, Xin F, Liu XL, Ren T, Zhang F, Xue Y, Cui A, Liu Z, Bai J, Liu Y, Cai G, Su W, Dai X, Shen F, Pan Q, Li Y*, Fan J*. Sodium butyrate supplementation inhibits hepatic steatosis by stimulating liver kinase B1 and insulin-induced gene. Cellular and Molecular Gastroenterology and Hepatology. 2021, 12(3):857-871

 

17. 刘雨笑, 苏维彤, 李于*. CREB/ATF碱性亮氨酸拉链转录因子在代谢和细胞生长中的生物学功能. 生理学报. 2021, 73(5): 761–771

 

18. Lin Q, Huang Z, Cai G, Fan X, Yan X, Liu Z, Zhao Z, Li J, Li J, Shi H, Kong M, Zheng M, Conklin D, Epstein P, Wintergerst K, Mohammadi M, Cai L, Li X, Li Y, Tan Y*. Activating AMP-activated protein kinase mediates fibroblast growth factor 1 protection from nonalcoholic fatty liver disease in mice. Hepatology. 2021, 73(6):2206-2222

 

19. Hou X, Yin S, Ren R, Liu S, Yong L, Liu L, Li Y, Zheng M, Kunos G, Gao B, Wang H*. Myeloid cell-specific IL-6 signaling promotes miR-223-enriched exosome production to attenuate NAFLD-associated fibrosis. Hepatology. 2021, 74(1):116-132

 

20. Zhu T, Zhao J, Zhuo S, Hu Z, Ouyang S, Wunier, Yu S, Chen Y, Li Y, Le Y*. High fat diet and high cholesterol diet reduce hepatic vitamin D-25-hydroxylase expression and serum 25-hydroxyvitamin D 3 level through elevating circulating cholesterol, glucose, and insulin levels. Molecular Nutrition and Food Research. 2021, e2100220

2020

21. Hu Z#, Han Y#, Liu Y, Zhao Z, Ma F, Cui A, Zhang F, Liu Z, Xue Y, Bai J, Wu H, Bian H, Chin YE, Yu Y, Meng Z, Wang H, Liu Y, Fan J, Gao X, Chen Y, Li Y*. CREBZF as a key regulator of STAT3 pathway in the control of liver regeneration in mice. Hepatology. 2020, 71(4):1421-1436

Highlighted: Maiers J, Schwartz R. CREBZF: Breaking the Cyclin of Liver Regeneration. 2020, 71(4):1145

 

22. Cui A#, Li J#, Ji S#, Ma F, Wang G, Xue Y, Liu Z, Gao J, Han J, Tai P, Wang T, Chen J, Ma X*, Li Y*. The effects of B1344, a novel fibroblast growth factor 21 analog, on nonalcoholic steatohepatitis in nonhuman primates. Diabetes. 2020, 69(8):1611-1623

Highlighted by Commentary: Kleinert M, Muller TD. A new FGF21 analog for the treatment of fatty liver disease. Diabetes. 2020, 69(8):1605-1607

 

23. Bai J, Xia M, Xue Y, Ma F, Cui A, Sun  Y, Han Y, Xu X, Zhang F, Hu Z, Liu Z, Liu Y, Cai G, Su W, Sun X, Wu H, Yan H, Chang X, Hu X, Bian H, Xia P, Gao J, Li Y*, Gao X*. Thrombospondin1 improves hepatic steatosis in diet-induced insulin-resistant mice and are associated with hepatic fat content in humans. EBioMedicine. 2020, 57:102849

Highlighted by Commentary: Song Y, Gao L. Thrombospondin1 as a potential therapeutic target for human nonalcoholic fatty liver disease. EBioMedicine. 2020, 58:102888

 

24. Shi D#, Xia X#, Cui A#, Xiong Z, Yan Y, Luo J, Chen G, Zeng Y, Cai D, Hou L, McDermott J, Li Y, Zhang H, Han J*. The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18 (Pten) and independent of daf-16. Nature Communications. 2020, 11:4496

 

25. Li M, He X, Guo W, Yu H, Zhang S, Wang N, Liu G, Sa R, Shen X, Jiang Y, Tang Y, Zhuo Y, Yin C, Tu Q, Li N, Nie X, Li Y, Hu Z, Zhu H, Ding J, Li Z, Liu T, Zhang F, Zhou H, Li S, Yue J, Yan Z, Cheng S*, Tao Y*, Yin H*. Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways. Nature Cancer. 2020, 1, 735–747

2019

26. Han Y#, Hu Z#, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y*. Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene. Nature Communications. 2019, 10:623

 

27. Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y*. The circadian protein Period2 suppresses mTORC1 activity via recruiting TSC1 to mTORC1 complex. Cell Metabolism. 2019, 29(3):653-667

 

28. Yang Y#, Ma F#, Liu Z, Su Q, Liu Y, Liu Z, Li Y*. The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3. Journal of Biological Chemistry. 2019, 294(3):772-782

 

29. Zhao Z, Xin F, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu X, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y*, Fan J*. Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats. Experimental and Molecular Medicine. 2019, 51(9):103

 

30. 胡志敏，刘雨笑，李于*.碱性亮氨酸拉链转录因子CREBZF通过STAT3通路调控肝脏组织再生. 临床肝胆病杂志. 2019, 35(11):2577.

 

31. Chen X, Zhuo S, Zhu T, Yao P, Yang M, Mei H, Li N, Ma F, Wang J, Chen S, Ye RD, Li Y, and Le Y*. Fpr2 deficiency alleviates diet-induced insulin resistance through reducing body weight gain and inhibiting inflammation mediated by macrophage chemotaxis and M1 polarization. Diabetes. 2019, 68(6):1130-1142

 

32. Xu X, Zhu X, Bai J, Xia P, Li Y, Lu Y, Li X, and Gao X*. Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3. FASEB Journal. 2019, 33(6):7289-7300

 

33. Xiao F, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, Li Y, Hu Z, Zhou Y, Li K, Han X, Fang Q, Jia W, Chen Y, Ying H, Zhai Q, Chen S, Guo F*. Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals. Molecular Metabolism. 2019, 20:138-148

 

34. Zhu X, Bian H, Wang L, Sun X, Xu X, Yan H, Xia M, Chang X, Lu Y, Li Y, Xia P, Li X, Gao X. Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway. Free Radic Biol Med. 2019, 141:192-204

 

35. Zheng Z, Zhang X, Liu X, Jin X, Dai L, Cheng H, Jing D, Thu P, Zhang M, Li H, Zhu J, Liu C, Xue B, Li Y, Chen L, Peng C, Zhu W, Wang L, Liu J, Li H, Li P, Xu X. Inhibition of HSP90β improves lipid disorders by promoting mature SREBPs degradation via the ubiquitin-proteasome system. Theranostics. 2019, 9(20):5769-5783

2018

36. Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y*. Hepatic CREBZF couples insulin to lipogenesis by inhibiting Insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology. 2018, 68(4):1361-1375

Highlighted by Commentary: Liu J*. Hepatic CREBZF as a novel transcriptional regulator of the lipogenic pathway. Metabolism Open. 2019;1:7-8

 

37. Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M*. DEPTOR suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease. Hepatology. 2018, 68(2):496-514

 

38. Sun Y, Xia M, Yan H, Han Y, Zhang F, Hu Z, Cui A, Ma F, Liu Z, Gong Q, Chen X, Gao J, Bian H, Tan Y, Li Y*, Gao X*. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21. British Journal of Pharmacology. 2018, 175(2):374-387

 

39. Zhang H, Yan S, Khambu B, Ma F, Li Y, Chen X, Martina JA, Puertollano R, Li Y, Chalasani N, Yin X-M*. Dynamic mtorc1-tfeb feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply. Autophagy. 2018, 14(10):1779-1795

 

40. 刘雨笑，张菲菲，李于*.肝脏CREBZF通过抑制Insig活性促进胰岛素诱导的脂质合成并加重饮食诱导的胰岛素抵抗小鼠的肝脏脂质沉积. 临床肝胆病杂志. 2018, 34(12):2661.

2017

41. Cui A, Hu Z, Han Y, Yang Y, Li Y*. Optimized analysis of In vivo and in vitro hepatic steatosis. Journal of Visualized Experiments. 2017, e55178

 

42. Chen L, Wang K, Long A, Jia L, Zhang Y, Deng H, Li Y, Han J, and Wang Y*. Fasting-induced hormonal regulation of lysosomal function. Cell Research. 2017, 27, 748-763

 

43. Sun Y, Yuan X, Zhang F, Han Y, Chang X, Xu X, Li Y, and Gao X*. Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells. Scientific Reports. 2017, 7, 11340

 

44. 崔奥媛, 李于*. 成纤维细胞生长因子21的前世今生：胰岛素增敏机制与临床研究. 中华糖尿病杂志. 2017, 9(1):18-21.

2016

45. Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y*. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1. Hepatology. 2016, 64(2):425-438

Highlighted by Editorial: Mahlapuu M, Marschall H-U*. Fibroblast growth factor 21 signaling: The liver in focus. Hepatology. 2016;64:333-335

 

46. Chen X, Zhang F, Gong Q, Cui A, Zhuo S, Hu Z, Han Y, Gao J, Sun Y, Liu Z, Yang Z, Le Y, Gao X, Dong LQ, Gao X, Li Y*. Hepatic ATF6 increases fatty acid oxidation to attenuate hepatic steatosis in mice through peroxisome proliferator-activated receptor alpha. Diabetes. 2016, 65(7):1904-1915

 

47. Zhuo S, Yang M, Zhao Y, Chen X, Zhang F, Li N, Yao P, Zhu T, Mei H, Wang S, Li Y, Chen S, Le Y*. Microrna-451 negatively regulates hepatic glucose production and glucose homeostasis by targeting glycerol kinase mediated gluconeogenesis. Diabetes. 2016, 65(11):3276-3288

Before 2015

48. 龚琦, 张菲菲, 韩亚美, 李于*. FGF21的代谢调控及临床应用. 中国细胞生物学学报. 2015, 37(4):460-468.

 

49. Li Y*, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M*, Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology. 2014, 146: 539-549.

 

50. Li Y, Xu S, Jiang B, Cohen RA, Zang M. Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs. PLoS ONE. 2013, 8(6): e67532.

 

51. Li Y*, Wong K, Walsh K, Gao B, Zang M*. Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. Journal of Biological Chemistry. 2013, 288:10490-10504.

 

52. DenBoer LM, Iyer A, McCluggage ARR, Li Y, Martyn AC, Lu R. JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation.Biochim Biophys Acta. 2013, 1829:921-929.

 

53. Verbeuren TJ, Xu S, Hou X, Bachschmid MM, Jiang B, Li Y, Zang M, Rupin A, Cohen RA. New aspects of vascular actions of polyphenols.Science MED. 2012, 3, 69-74.

 

54. Tan Z, Zhou L, Li Y, Cui Y, Xiang Q, Lin G, and Wang T. E2 - BSA activates caveolin-1 via PI3K/ERK1/2 and lysosomal degradation pathway and contributes to EPC proliferation. Int J Cardiol. 2012, 158, 46-53.

 

55. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JJ, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, and Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in Diet-Induced insulin-resistant mice. Cell Metabolism. 2011, 13, 376-388.

Citation 509, top 4 most cited papers published by Cell Metabolism since 2011, and highlighted as “Highly Cited Paper”. https://apps.webofknowledge.com

 

56. Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB Journal. 2011, 25, 1664-79.

 

57. Audas TE, Li Y, Liang G, and Lu R. A novel protein, Luman/CREB3 recruitment factor (LRF), inhibits Luman activation of the unfolded protein response. Molecular and Cellular Biology. 2008, 28, 3952-66.

 

58. Liang G, Audas TE, Li Y, Cockram GP, Dean JD, Martyn AC, Kokame K, and Lu R. Luman/CREB3 induces transcription of the endoplasmid reticulum (ER) stress response protein Herp through an ER stress response element. Molecular and Cellular Biology. 2006, 26, 7999-8010.